2025 NCAA Women’s March Madness: Betting Odds, BPI Projections & Key Matchups to Watch

The 2025 NCAA Women’s March Madness is heating up as 64 teams battle for the championship glory. The UCLA Bruins, after dominating the Big 10 tournament, secured the coveted No. 1 overall seed. Meanwhile, the reigning champions, South Carolina, aim to defend their title under the leadership of head coach Dawn Staley.

Key Matchups and Betting Insights

Duke vs. Oregon - Regional 2, Birmingham

• Spread: Duke -14.5
• Moneyline: Duke (-2000), Oregon (+1000)
• Total: 124.5
• BPI Projection: Duke by 16.2, 92.2% win probability

Notre Dame vs. Michigan - Regional 3, Birmingham

• Spread: Notre Dame -14.5
• Moneyline: Notre Dame (-1800), Michigan (+900)
• Total: 153.5
• BPI Projection: Notre Dame by 12.8, 87.5% win probability

Kansas State vs. Kentucky - Regional 4, Spokane

• Spread: Kansas State -2.5
• Moneyline: Kansas State (-140), Kentucky (+120)
• Total: 140.5
• BPI Projection: Kansas State by 3.2, 61.8% win probability

South Carolina vs. Indiana - Regional 2, Birmingham

• Spread: South Carolina -22.5
• Moneyline: South Carolina (-50000), Indiana (+3500)
• Total: 136.5
• BPI Projection: South Carolina by 20.1, 95.6% win probability

Baylor vs. Ole Miss - Regional 1, Spokane

• Spread: Baylor -3.5
• Moneyline: Baylor (-150), Ole Miss (+125)
• Total: 136.5
• BPI Projection: Baylor by 3.7, 63.9% win probability

Stars to Watch

This year’s tournament sees new talents like JuJu Watkins (USC) and Joyce Edwards (South Carolina) stepping up in the absence of legends like Caitlin Clark and Angel Reese. Paige Bueckers (UConn) is also a player to watch as she leads her team in her final season.

Broadcast Details

Catch all the action from the First Four to the Final Four on ABC, ESPN, ESPN2, ESPNU, and ESPNEWS. Stay updated with the latest odds on ESPN BET.

Odds are accurate as of publication time. All times are in Eastern Time. For the latest odds, visit ESPN BET.