2025 NCAA March Madness: Betting Odds, Key Matchups, and BPI Projections

The 2025 NCAA March Madness tournament is in full swing, with 68 teams vying for the championship title. The Auburn Tigers, the overall No. 1 seed in the South, are looking to redeem themselves after their SEC tournament loss and claim the national title. The SEC has made a strong showing with 14 teams in the tournament, but they face stiff competition from powerhouse teams like Houston and a rejuvenated Duke Blue Devils squad led by Cooper Flagg.

Friday - Round 1

Baylor Bears vs. Mississippi State Bulldogs

• Spread: Mississippi State -1.5
• Moneyline: Mississippi State (-125), Baylor (+105)
• Total: 145.5
• BPI Projection: Baylor by 3, straight up: 61.6%

Robert Morris Colonials vs. Alabama Crimson Tide

• Spread: Alabama -22.5
• Moneyline: Alabama (-7500), Robert Morris (+2000)
• Total: 166.5
• BPI Projection: Alabama by 21, straight up: 96.7%

Lipscomb Bisons vs. Iowa State Cyclones

• Spread: Iowa State -14.5
• Moneyline: Iowa State (-1600), Lipscomb (+800)
• Total: 142.5
• BPI Projection: Iowa State by 15.6, straight up: 92.4%

Colorado State Rams vs. Memphis Tigers

• Spread: Colorado State -1.5
• Moneyline: Colorado State (-120), Memphis (+EVEN)
• Total: 146.5
• BPI Projection: Memphis by 0.8, straight up: 53.3%

Mount St. Mary's Mountaineers vs. Duke Blue Devils

• Spread: Duke -32.5
• Moneyline: Duke (-50000), Mount St. Mary's (+3000)
• Total: 140.5
• BPI Projection: Duke by 30.6, straight up: 99.3%

Saturday - Round 2

McNeese Cowboys vs. Purdue Boilermakers

• Spread: Purdue -5.5
• Moneyline: Purdue (-240), McNeese (+200)
• Total: 143.5
• BPI Projection: Purdue by 7.5, straight up: 76.8%

Arkansas Razorbacks vs. St. John's Red Storm

• Spread: St. John's -7.5
• Moneyline: St. John's (-300), Arkansas (+250)
• Total: 144.5
• BPI Projection: St. John's by 5.7, straight up: 71.3%

Michigan Wolverines vs. Texas A&M Aggies

• Spread: Texas A&M -2.5
• Moneyline: Texas A&M (-140), Michigan (+120)
• Total: 140.5
• BPI Projection: Texas A&M by 2.1, straight up: 58.1%

Drake Bulldogs vs. Texas Tech Red Raiders

• Spread: Texas Tech -7.5
• Moneyline: Texas Tech (-380), Drake (+290)
• Total: 127.5
• BPI Projection: Texas Tech by 10.4, straight up: 84.1%

Creighton Bluejays vs. Auburn Tigers

• Spread: Auburn -8.5
• Moneyline: Auburn (-450), Creighton (+340)
• Total: 150.5
• BPI Projection: Auburn by 7.4, straight up: 76.5%

Stay tuned for more updates and analysis as the tournament progresses. For the latest odds and insights, visit ESPN BET.