MLB Opening Day 2025: Full Schedule, Key Matchups, and Season Previews

The 2025 MLB season is set to kick off with a bang, as 28 of the 30 teams take the field on March 27 for Opening Day. ESPN will be broadcasting two of the most anticipated games: the Milwaukee Brewers vs. New York Yankees in the late afternoon, followed by a primetime showdown between the reigning champion Los Angeles Dodgers and the Detroit Tigers. The Tampa Bay Rays and Colorado Rockies will start their season on March 28.

Key Pitching Matchups

Thirty of the league's top pitchers will be on the mound, including 22 All-Stars. Notable debuts include four pitchers making their first appearances for new clubs and one who will become the fastest top overall pick to start in a season opener.

Opening Day Schedule

Here’s the full schedule for Opening Day (all times ET):

• 3:05 p.m. on ESPN: Milwaukee Brewers at New York Yankees

  • Pitching matchup: Freddy Peralta vs. Carlos Rodón

• 3:07 p.m.: Baltimore Orioles at Toronto Blue Jays

  • Pitching matchup: Zach Eflin vs. Jose Berrios

• 4:05 p.m.: Boston Red Sox at Texas Rangers

  • Pitching matchup: Garrett Crochet vs. Nathan Eovaldi

• 4:05 p.m.: Philadelphia Phillies at Washington Nationals

  • Pitching matchup: Zack Wheeler vs. MacKenzie Gore

• 4:10 p.m.: Cleveland Guardians at Kansas City Royals

  • Pitching matchup: TBD vs. Cole Ragans

• 4:10 p.m.: New York Mets at Houston Astros

  • Pitching matchup: Clay Holmes vs. Framber Valdez

• 4:10 p.m.: San Francisco Giants at Cincinnati Reds

  • Pitching matchup: Logan Webb vs. Hunter Greene

• 4:10 p.m.: Atlanta Braves at San Diego Padres

  • Pitching matchup: Chris Sale vs. Michael King

• 4:10 p.m.: Los Angeles Angels at Chicago White Sox

  • Pitching matchup: Yusei Kikuchi vs. Sean Burke

• 4:10 p.m.: Pittsburgh Pirates at Miami Marlins

  • Pitching matchup: Paul Skenes vs. Sandy Alcantara

• 4:15 p.m.: Minnesota Twins at St. Louis Cardinals

  • Pitching matchup: Pablo Lopez vs. Sonny Gray

• 7:10 p.m. on ESPN: Detroit Tigers at Los Angeles Dodgers

  • Pitching matchup: Tarik Skubal vs. TBD

• 10:10 p.m.: Chicago Cubs at Arizona Diamondbacks

  • Pitching matchup: TBD vs. TBD

• 10:10 p.m.: Athletics at Seattle Mariners

  • Pitching matchup: Luis Severino vs. Logan Gilbert

March 28 Game

• 4:10 p.m.: Colorado Rockies at Tampa Bay Rays
  • Pitching matchup: Kyle Freeland vs. Shane McClanahan

Season Previews and Analysis

To get you fully prepared for the 2025 season, we’ve got you covered with comprehensive season previews, fantasy baseball cheat sheets, and expert analysis. Jeff Passan’s 2025 season preview offers predictions, inside intel, and breakout stars for all 30 teams. Additionally, keep an eye on the top prospects in MLB’s Spring Breakout, as young players look to make their mark this season.

Stay tuned for what promises to be an exciting start to the 2025 MLB season!