NFL Week 2 2025: Expert Predictions, Key Matchups, and Game Previews
Get ready for NFL Week 2 with expert predictions, in-depth game previews, and key insights into the most exciting matchups of the 2025 season.

NFL Week 2 2025: Game Previews and Predictions
The second week of the 2025 NFL season is packed with thrilling matchups, including some high-stakes rematches and intriguing storylines. Here’s a breakdown of what to expect:
Lions vs. Bears: A Homecoming for Ben Johnson
The Lions will face their former offensive coordinator, Ben Johnson, now with the Bears. Detroit is looking to avoid an 0-2 start, while Chicago aims to improve their offensive consistency.
- Key Stat: Jared Goff is chasing history, aiming to win 11 straight games after a loss.
- Bold Prediction: The Bears will record at least three 30-plus-yard plays.
Bills vs. Jets: AFC East Showdown
The Bills and Jets clash in a divisional rivalry. Buffalo’s defense will be tested against a rejuvenated Jets offense that put up 32 points in Week 1.
- Key Stat: Josh Allen has 18 career turnovers against the Jets.
- Bold Prediction: Jets CB Brandon Stephens will be targeted at least nine times.
Ravens vs. Browns: Battle in the AFC North
The Ravens, led by Lamar Jackson, face a tough Browns defense. Cleveland will need to contain Derrick Henry to have a chance.
- Key Stat: The Ravens are 12-2 following a loss since 2022.
- Bold Prediction: Mark Andrews will bounce back with five receptions and a TD.
Chiefs vs. Eagles: Super Bowl Rematch
A highly anticipated rematch of Super Bowl LIX, the Chiefs and Eagles will battle it out in Kansas City. Both teams are looking to make an early statement.
- Key Stat: This is the fourth Super Bowl rematch in Week 1 or 2.
- Bold Prediction: Eagles’ Joshua Uche will force a critical Mahomes mistake.
Other Notable Matchups:
- Jaguars vs. Bengals: Joe Burrow faces Trevor Lawrence in a battle of former college stars.
- Seahawks vs. Steelers: Both teams look to rebound after Week 1 struggles.
- 49ers vs. Saints: San Francisco aims to overcome injuries to key players.
Expert Picks and Predictions
Our analysts have weighed in with their final score predictions for every game. Here’s a quick look:
- Lions vs. Bears: Analysts are split, but the Lions are favored.
- Bills vs. Jets: Buffalo is expected to edge out the Jets.
- Ravens vs. Browns: Baltimore is heavily favored to win.
- Chiefs vs. Eagles: A close game, but the Eagles are slightly favored.
Fantasy and Betting Insights
- Fantasy Nugget: Keep an eye on Travis Etienne Jr. against the Bengals’ defense.
- Betting Nugget: The Bills have covered three straight meetings against the Jets.
Conclusion
Week 2 of the 2025 NFL season promises to deliver excitement, drama, and plenty of action. Whether you’re a fan, fantasy manager, or bettor, these games are not to be missed!