2025 Fantasy Football Draft Guide: Perfect Picks for Every Round in a 12-Team League

Mike Clay's ultimate guide to the 2025 fantasy football draft, featuring round-by-round picks and strategies for a 12-team league.

Fantasy football drafts are all about maximizing value while securing those special players who can elevate your team. Whether it’s a breakout tight end, a sleeper running back, or a rising star wide receiver, these players add excitement and potential to your roster. Here’s a round-by-round breakdown of the ideal picks for a 12-team league in 2025, based on Mike Clay’s expert analysis.

Round 1: Best Available Wide Receiver or Bijan Robinson

In the first round, securing an elite wide receiver like Justin Jefferson, CeeDee Lamb, or Amon-Ra St. Brown is often the best move. However, if you land a top-two pick, Bijan Robinson is the ultimate prize. His combination of youth, talent, and workload makes him a tier above other running backs.

Round 2: Jonathan Taylor or Best Running Back Available

If you miss out on Robinson, Jonathan Taylor is a solid second-round option. Despite the Colts' QB concerns, Taylor remains a feature back with significant upside. Other enticing options include De'Von Achane and Kyren Williams.

Round 3: Trey McBride or Top Tight End

Targeting a top tight end like Trey McBride or Brock Bowers in the third round can give you a significant edge. McBride’s high target volume and potential for a heavy workload make him a valuable pick.

Round 4: Elite Dual-Threat Quarterbacks

This year, elite dual-threat QBs like Lamar Jackson, Josh Allen, and Jalen Hurts are available as late as the fourth round. Their rushing contributions provide a significant fantasy advantage.

Round 5: James Conner or Reliable Veterans

James Conner is a reliable option in the fifth round, offering consistent production and a high floor. Other solid picks include D'Andre Swift and DK Metcalf.

Round 6: TreVeyon Henderson or Breakout Candidates

Rookie TreVeyon Henderson has the potential to be a significant contributor in the Patriots' offense. Other breakout candidates include Calvin Ridley and George Pickens.

Middle Rounds: Depth and Upside

Rounds 7-10 are about filling gaps and adding depth. Players like Jaylen Waddle, Rome Odunze, and Michael Pittman Jr. offer both upside and reliability.

Late Rounds: High-Ceiling Fliers

In the later rounds, target high-upside players like Colston Loveland, Jayden Higgins, and Keon Coleman. These players can provide significant value if they break out.

Final Rounds: Kicker and Defense

If your league requires a kicker and defense, wait until the final rounds. Focus on streaming options and matchups rather than reaching for top-tier defenses.

Conclusion

This draft guide is designed to help you build a championship-caliber team in 2025. Remember, flexibility and adaptability are key. Use this as a foundation, but always be ready to adjust based on how your draft unfolds.

What to Read Next

New Orleans Saints' Quarterback Battle Heats Up: Shough vs. Rattler for Week 1 Start
NFL

New Orleans Saints' Quarterback Battle Heats Up: Shough vs. Rattler for Week 1 Start

The New Orleans Saints are nearing a decision on their starting quarterback for Week 1, with Tyler Shough and Spencer Rattler in a tight race.

Rising Star Upton Stout: The 49ers' Rookie Cornerback Making Waves in the NFL
NFL

Rising Star Upton Stout: The 49ers' Rookie Cornerback Making Waves in the NFL

Discover how Upton Stout, the 49ers' rookie cornerback, is quickly making a name for himself in the NFL with his relentless work ethic and competitive spirit.

Falcons' Darnell Mooney's Return: A Game-Changer for Atlanta's Offense
NFL

Falcons' Darnell Mooney's Return: A Game-Changer for Atlanta's Offense

The Atlanta Falcons eagerly await the return of injured wide receiver Darnell Mooney, hoping his comeback will boost their offensive game in the upcoming NFL season.

Bryce Young and C.J. Stroud: A Bond Beyond the Gridiron
NFL

Bryce Young and C.J. Stroud: A Bond Beyond the Gridiron

Explore the enduring friendship and rivalry between NFL quarterbacks Bryce Young and C.J. Stroud, from their childhood to the pros.

Nik Bonitto: Rising Star in the NFL - Can He Dominate the 2025 Season?
NFL

Nik Bonitto: Rising Star in the NFL - Can He Dominate the 2025 Season?

Explore Nik Bonitto's journey from a breakout season to becoming a key player for the Denver Broncos in 2025. Will he continue to dominate?

Arizona Cardinals' Young Cornerbacks Rise to the Challenge Amid Injuries
NFL

Arizona Cardinals' Young Cornerbacks Rise to the Challenge Amid Injuries

Injuries to key players have opened doors for Arizona Cardinals' young cornerbacks to step up and shine in the 2025 NFL season.

NFL Preseason Week 2 Highlights: Elic Ayomanor Shines as Titans Defeat Falcons
NFL

NFL Preseason Week 2 Highlights: Elic Ayomanor Shines as Titans Defeat Falcons

Week 2 of the 2025 NFL preseason saw rookie Elic Ayomanor lead the Titans to a narrow victory over the Falcons. Get the full game recap and key takeaways.

NFL 2025 Positional Power Rankings: Who Leads the Pack?
NFL

NFL 2025 Positional Power Rankings: Who Leads the Pack?

Explore the comprehensive 2025 NFL positional rankings, from quarterback to safety, and discover which teams are set to dominate this season.

Behind the Scenes at Dallas Cowboys' Training Camp: Laughter, Oddities, and Team Spirit
NFL

Behind the Scenes at Dallas Cowboys' Training Camp: Laughter, Oddities, and Team Spirit

Explore the lighter side of the Dallas Cowboys' training camp in Oxnard, featuring unique moments, player antics, and team camaraderie.

From Rugby to Raiders: Laki Tasi's NFL Journey as a 373-Pound Australian Offensive Lineman
NFL

From Rugby to Raiders: Laki Tasi's NFL Journey as a 373-Pound Australian Offensive Lineman

Discover how Laki Tasi, a 373-pound Australian rugby player, is making waves in the NFL with the Las Vegas Raiders through the International Pathway Program.

How Titans' Jeffery Simmons and JC Latham Transformed Their Bodies for NFL Dominance
NFL

How Titans' Jeffery Simmons and JC Latham Transformed Their Bodies for NFL Dominance

Discover how Tennessee Titans stars Jeffery Simmons and JC Latham reshaped their bodies for peak performance in the NFL.

Cooper Rush Returns to Dallas as Ravens' Backup QB: A New Chapter Begins
NFL

Cooper Rush Returns to Dallas as Ravens' Backup QB: A New Chapter Begins

Cooper Rush returns to Dallas as the Baltimore Ravens' backup QB, ready to prove his worth in the NFL preseason.

J.J. McCarthy's Stellar Performance in Practice: A Glimpse into the Vikings' Future
NFL

J.J. McCarthy's Stellar Performance in Practice: A Glimpse into the Vikings' Future

J.J. McCarthy shines in joint practice with the Patriots, showcasing his potential as the Vikings' future quarterback under coach Kevin O'Connell's guidance.

Detroit Lions' New Coordinators: What to Expect from John Morton and Kelvin Sheppard in the 2025 NFL Season
NFL

Detroit Lions' New Coordinators: What to Expect from John Morton and Kelvin Sheppard in the 2025 NFL Season

Discover how Detroit Lions' new coordinators, John Morton and Kelvin Sheppard, are shaping the team for the 2025 NFL season with their unique coaching styles and strategies.

2025 NFL Deep Sleepers: Hidden Gems to Watch in Fantasy Football
NFL

2025 NFL Deep Sleepers: Hidden Gems to Watch in Fantasy Football

Discover the under-the-radar NFL players poised to make a significant impact in the 2025 fantasy football season.

Load More

We use essential cookies to make our site work. With your consent, we may also use non-essential cookies to improve user experience and analyze website traffic. By clicking "Accept," you agree to our website's cookie use as described in our Cookie Policy.