2025 NCAA Women's Sweet 16: Expert Predictions, Key Players, and Game Breakdowns

2025 NCAA Women's Sweet 16 Preview

The 2025 NCAA Women's Basketball Tournament has reached the Sweet 16, and the stage is set for some thrilling matchups in Birmingham, Alabama, and Spokane, Washington. With powerhouse programs and star players taking center stage, this year’s regional semifinals promise intense competition and unforgettable moments.

Key Matchups and Predictions

(2) Duke vs. (3) North Carolina

Why North Carolina Wins: Alyssa Ustby’s dominance in their first meeting this season was the difference. Her return to form could tip the scales in favor of the Tar Heels.

Why Duke Wins: The Blue Devils’ relentless defense under Kara Lawson has been their backbone. If they can maintain their defensive intensity, they’ll have a strong chance to advance.

X Factor: Reigan Richardson’s scoring resurgence could be the spark Duke needs to overcome their rivals.

Prediction: Duke 61, North Carolina 57

(1) South Carolina vs. (4) Maryland

Why South Carolina Wins: Depth and versatility give the Gamecocks an edge. Their ability to adapt and dominate in multiple facets of the game makes them a formidable opponent.

Why Maryland Wins: The Terrapins’ ability to score under pressure, especially against a high-tempo defense like South Carolina’s, could be the key to an upset.

X Factor: MiLaysia Fulwiley’s consistency will be crucial for South Carolina’s championship aspirations.

Prediction: South Carolina 75, Maryland 59

(2) NC State vs. (3) LSU

Why NC State Wins: The Wolfpack have tightened their play since their early-season loss to LSU. Madison Hayes’ rebounding and shooting could be the difference.

Why LSU Wins: The Tigers’ trio of Flau’Jae Johnson, Aneesah Morrow, and Mikaylah Williams is one of the most dynamic in college basketball.

X Factor: LSU’s supporting cast must step up to complement their stars and secure the win.

Prediction: LSU 81, NC State 78

(1) UCLA vs. (5) Ole Miss

Why UCLA Wins: Lauren Betts’ dominance in the paint makes the Bruins a tough matchup for any team, especially a smaller Ole Miss squad.

Why Ole Miss Wins: The Rebels’ battle-tested defense and experience against top-tier opponents could give them an edge.

X Factor: Kiki Rice’s ability to capitalize on defensive attention will be crucial for UCLA’s success.

Prediction: UCLA 72, Ole Miss 53

Full Sweet 16 Schedule and Analysis

For more in-depth analysis and predictions on every Sweet 16 game, including matchups like Texas vs. Tennessee and UConn vs. Oklahoma, stay tuned to ESPN’s coverage of the 2025 NCAA Women’s Tournament.