2025 NCAA Women's March Madness: First Round Betting Odds, Spreads, and Key Matchups

The 2025 NCAA Women's March Madness tournament is set to begin with 68 teams vying for the championship title. The UCLA Bruins have secured the overall No. 1 seed after a dominant performance in the Big 10 tournament, while reigning champions South Carolina aim to defend their title under head coach Dawn Staley.

Key Teams to Watch

• UCLA Bruins: The top-seeded team with a strong season record.
• South Carolina Gamecocks: Defending champions looking to repeat their success.
• USC Trojans: Led by JuJu Watkins and Kiki Iriafen, they are strong contenders.
• UConn Huskies: Paige Bueckers aims to lead her team to victory in her final year.

First Round Matchups and Betting Odds

Here are the pregame lines, spreads, and totals for the opening round matchups:

Wednesday - First Four

• Princeton Tigers vs. Iowa State Cyclones: Iowa State favored by 4.5 points.
• Southern Jaguars vs. UC San Diego Tritons: UC San Diego favored by 2.5 points.

Thursday - First Four

• Washington Huskies vs. Columbia Lions: Washington favored by 1.5 points.
• William & Mary Tribe vs. High Point Panthers: High Point favored by 4.3 points.

Friday - Round 1

• Iowa State/Princeton vs. Michigan Wolverines: Michigan's betting lines to be determined.
• Liberty Flames vs. Kentucky Wildcats: Kentucky favored by 16.5 points.

How to Watch

Catch every game from the First Four to the Final Four on ABC, ESPN, ESPN2, ESPNU, and ESPNEWS. All times are Eastern.

For the latest odds and updates, visit ESPN BET.